MOTS-c
$89.99
Also known as: Motsc, Mots Peptide, Mots-c Peptide
MOTS-c Research Peptide
MOTS-C is a 16-amino acid mitochondrial-derived peptide and is supplied online in Australia from Peptide House.
Mots-C was discovered in 2015 by Changhan Lee at USC and research has mostly been conducted on cells and live animals.
The 2015 paper made a few key findings from cell and mouse research. It was found that the 16-amino acid peptide that the team later named Mots-c showed that the compound could regulate insulin sensitivity and metabolism. The second finding was it helps muscle cells to a more energy efficient, fuel burning state. Lastly, mice that were given Mots-c didn’t gain the weight expected when they were fed an extremely fatty diet and kept responding to insulin normally, even on that same diet.
Product Specifications
- Form: Lyophilised powder
- Quantity: 10mg per vial
- Purity: >98% (HPLC verified)
- Storage: 2-8C, protect from light
For research purposes only. Not approved for human or animal use. Not TGA evaluated.
Frequently Asked Questions
What is MOTS-c Peptide?
It functions as a signalling molecule with hormone-like activity. In laboratory studies it acts primarily on skeletal muscle, where it inhibits the folate cycle and activates AMPK, a key regulator of cellular energy metabolism. This shifts cells toward greater glucose uptake and fatty acid oxidation, an effect often compared to that of exercise. Endogenous levels have been observed to rise in response to exercise and decline with age.
Has there been research done on MOTS-c?
Yes, by Chanhan LeeMany findings were found being MOTS-c is a mitochondrial-encoded peptide that regulates metabolism. It activates AMPK in skeletal muscle, increasing glucose and fat utilisation. In mice, it prevented diet-induced obesity and insulin resistance caused by high-fat diets and ageing.
Can MOTS-C be bought online in Australia?
Yes. MOTS-c can be bought online in Australia from peptide suppliers such as Peptide House. However, MOTS-c is not TGA-approved for human therapeutic use and is considered an unapproved peptide product.
Is MOTS-c known as anything else?
Yes, sometimes it is referred to as mots or MOTS in community forums, Mitokine if you prefer a more scientific name or by the few different ways to write it such as motsc .
Can I get MOTS-c at a pharmacy?
Not as a normal off-the-shelf pharmacy medicine. MOTS-c is not TGA-approved in Australia, so you generally can’t walk into Chemist Warehouse or a regular pharmacy and buy it. In limited circumstances, a doctor may prescribe an unapproved or compounded medicine for an individual patient, and a compounding pharmacy may then supply it if the legal requirements are met.
How do you reconstitute MOTS-c?
In general, “reconstitution” means adding a specified sterile diluent to a lyophilised powder to reach a known concentration, but the correct amount of diluent can be found via our Peptide Calculator. We also highly recommend that all research is done using BAC water.
How does MOTS-c work?
MOTS-c acts through two mechanisms. In skeletal muscle, it activates AMPK, the cell's primary energy regulator, promoting the use of glucose and fat for energy while reducing fat storage. Under cellular stress, it relocates to the nucleus, where it activates genes involved in stress resistance and cellular protection.
Where to buy MOTS-c in Australia?
If you want to purchase MOTS-c in Australia for research, one suitable option is purchasing from an online retailer such as Peptide House.
Why is MOTS-c referred to as a research chemical?
MOTS-c is sold as a research chemical as it is not FDA approved and subsequently TGA approved. All Peptides sold on this website are intended for research use and not sold for human consumption